The Chiefs made their first roster cuts to get down to the 75-player limit before Tuesday’s deadline.
Other cuts included quarterback Ricki Stanzi, who was beat out for the third quarterback by Tyler Bray.
Wilson was in competition with Anthony Sherman, who was acquired from the Phoenix Cardinals.
He appeared in 29 games the past two seasons for the Cardinals.
Wilson was known as a pure lead-blocker for the Wildcats.
Wilson carried the ball just 39 times in four seasons at Kansas State.
Third-round pick Knile Davis helped his cause with a 109-yard kickoff return Saturday in the 26-20 overtime victory over Pittsburgh.
The other cuts included:
CB Vince Agnew
DE Miguel Chavis
WR Terrance Copper
OL Ryan Durand
OL Hutch Eckerson
DB Otha Foster III
OL AJ Hawkins
DE Rob Lohr
CB Kamaal McIlwain
RB Jordan Roberts
WR Tyler Shoemaker
DB Neiko Thorpe