Vanderpool had scoring runs of 38, 41, 4 and 15 yards. Caleb Dickey returned a punt for 38 yards for a touchdown.
Vanderpool led the Trojans in rushing with 66 yards and had five tackles on defense. Matt Jones also had five tackles.
Hartford was held to 82 yards of offense. MdCV rushed for 135 yards and passed for 25. Jones caught a pass for 19 yards.
MdCV (1-0) plays 7 p.m. Friday at Madison.